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Evidence for a role for the p110-α isoform of PI3K in skeletal function

✍ Scribed by Andrew Grey; Claire Chaussade; Victoria Empson; Jian-Ming Lin; Maureen Watson; Susannah O’Sullivan; Gordon Rewcastle; Dorit Naot; Jillian Cornish; Peter Shepherd

Book ID: 116299514
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 837 KB
Volume: 391
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.11.099

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PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost inva