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Evidence for a Novel Exon in the Coding Region of the Adenomatous Polyposis Coli (APC) Gene

✍ Scribed by Ling Xia; Kelly A. St. Denis; Bharati Bapat

Book ID
115612757
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
245 KB
Volume
28
Category
Article
ISSN
0888-7543

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We report the genomic cloning and sequence analysis of a novel and (so far) smallest coding exon of the human adenomatous polyposis coli (APC) gene. This additional exon of 54 nucleotides in length, designated APC exon 10A, is located 1.6 kb downstream from exon 10. It resides on a 0.5-kb genomic Ec

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## Germline mutations within the adenomatous polyposis coli (APC ) gene, a tumor suppressor gene, are responsible for most cases of familial adenomatous polyposis (FAP), an autosomal dominantly inherited predisposition to colorectal cancer. To date, more than 300 germ-line causative mutations with