Continual reassessment methods in phase
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Andrew Kramar; Anne Lebecq; Emmanuel Candalh
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Article
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1999
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John Wiley and Sons
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English
β 153 KB
π 2 views
Most phase I trials in oncology use standard methods for treating successive groups of patients with increasing doses in order to determine the maximum tolerated dose (MTD). These methods have been criticized because they treat many patients at suboptimal dose levels, and do not provide an accurate