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Pediatric phase I trial and pharmacokinetic study of ‘Tomudex’ (Ralitrexed)

✍ Scribed by Widemann, B.C.; Balis, F.M.; Reaman, G.H.; Sato, J.; O'Brien, M.; Krailo, M.; Lowery, C.; Adamson, P.C.


Book ID
122675559
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
144 KB
Volume
35
Category
Article
ISSN
0959-8049

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Eflornithine-HCl (alpha-difluoromethylornithine or DFMO), an irreversible inhibitor of ornithine decarboxylase, blocks polyamine synthesis and has demonstrated antitumor activity in cell culture and animal tumor models. This phase I study was designed to determine and compare toxicity and the maxima