Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
โฆ LIBER โฆ
Evaluation of two different models to predict BRCA1 and BRCA2 mutations in a cohort of Danish hereditary breast and/or ovarian cancer families
โ Scribed by A-M Gerdes; DG Cruger; M Thomassen; TA Kruse
- Book ID
- 110888157
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 100 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0009-9163
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The presence of genomic rearrangements of the BRCA1 gene in breast and/or ovarian cancer families has been intensively investigated in patients from various countries over the last years. A number of different rearrangements have been reported by several studies that clearly document the involvement