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Evaluation of theCited2 gene and risk for spina bifida and congenital heart defects

โœ Scribed by Volcik, Kelly A. ;Zhu, Huiping ;Finnell, Richard H. ;Shaw, Gary M. ;Canfield, Mark ;Lammer, Edward J.


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
40 KB
Volume
126A
Category
Article
ISSN
0148-7299

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## Abstract __TXN2__ encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. __Txn2__ knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human __TXN