## Abstract ## BACKGROUND: Moderate hyperhomocysteinemia is a known risk factor for NTDs in a variety of experimental model systems and is believed to be important in humans as well. The enzyme nicotinamide __N__βmethyl transferase (NNMT) was identified in a genomeβwide linkage scan as being an im
Phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphisms and risk of spina bifida
β Scribed by Jing Zhang; Huiping Zhu; Wei Yang; Gary M. Shaw; Edward J. Lammer; Richard H. Finnell
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 90 KB
- Volume
- 140A
- Category
- Article
- ISSN
- 1552-4825
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract **BACKGROUND:**__PAX3__ plays an important role in mammalian embryonic development. Known mutations in __PAX3__ are etiologically associated with Waardenburg syndrome and syndromic neural tube defects (NTDs). Mutations in the murine homologue, __pax3__, are responsible for the phenotype
## Abstract __TXN2__ encodes human thioredoxin 2, a small redox protein important in cellular antioxidant defenses, as well as in the regulation of apoptosis. __Txn2__ knockout mice fail to complete neural tube closure by E10.5 and die in utero. We hypothesized that genetic variation in human __TXN
## Abstract ## Background __PRKACA__ and __PRKACB__ are genes encoding the cAMPβdependent protein kinase A (PKA) catalytic subunits alpha and beta, respectively. PKA is known to be involved in embryonic development, as it downregulates the Hedgehog (Hh) signaling pathway, which is critical to norm