## Abstract ## BACKGROUND Several studies have suggested that homozygosity for the C677T 5,10βmethylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs), as individuals homozygous for the C677T allele have slightly elevated homocysteine concentrat
Methylenetetrahydrofolate reductase and spina bifida: Evaluation of level of defect and maternal genotypic risk in Hispanics
β Scribed by Volcik, K.A. ;Blanton, S.H. ;Tyerman, G.H. ;Jong, S.T. ;Rott, E.J. ;Page, T.Z. ;Romaine, N.K. ;Northrup, H.
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 131 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0148-7299
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Spina bifida cystica (SB) is one of the most common and disabling of birth defects. Folic acid supplementation in mothers during the periconceptional period has been shown to prevent more than 70% of neural tube defects (NTD) including SB. However, the mechanism is unknown. We tested a series of mul
Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C¨T, is the first genetic risk factor for NTDs in man identified at the molec