## Abstract ## Background: Activation of the mammalian target of rapamycin (mTOR) pathway in surgical margins of head and neck squamous cell carcinoma (HNSCC) is a predictor of recurrence and patients with minimal residual disease may benefit from adjuvant therapy with temsirolimus, an mTOR inhibi
Evaluation of the newly updated TNM classification of head and neck carcinoma with data from 3247 patients
β Scribed by Heinrich Iro; Frank Waldfahrer
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 97 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0008-543X
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β¦ Synopsis
BACKGROUND.
The fifth edition of the TNM classification contains a number of changes concerning head and neck tumors. The division of Stage IV tumors into three subcategories marks a significant expansion of the stage grouping procedure.
METHODS.
In a retrospective study, the clinical courses of 3247 patients with carcinoma of the oral cavity, the oro-and hypopharynx, the larynx, the salivary glands, and the maxillary sinus were comparatively evaluated according to the fourth and fifth editions of the TNM classification agreed upon by the International Union Against Cancer and the American Joint Committee on Cancer. The particular aim of this study was to test the prognostic relevance of the subdivision of Stage IV, especially for mucosal carcinoma.
RESULTS.
In classifying the primary tumor, the most extensive changes were noted for supraglottic and salivary gland tumors. On the basis of the fourth edition of the TNM classification, the following recurrence free 5-year survival rates for 3033
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## Background: The benefits of ct scanning of the chest and abdomen as a routine screening method for patients with newly diagnosed head and neck squamous cell carcinoma (hnscc) remain unclear. ## Methods: Consecutive patients with a primary hnscc (t classification, t2-t4) and or regionally metas
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