✦ LIBER ✦

Pharmacodynamic evaluation of temsirolimus in patients with newly diagnosed advanced-stage head and neck squamous cell carcinoma

✍ Scribed by Oleksandr Ekshyyan; Glenn M. Mills; Timothy Lian; Nazanin Amirghahari; Xiaohua Rong; Mary Lowery-Nordberg; Fleurette Abreo; Diana M. Veillon; Gloria Caldito; Lisa Speicher; Jonathan Glass; Cherie-Ann O. Nathan

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 244 KB
Volume: 32
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.21374

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background:

Activation of the mammalian target of rapamycin (mTOR) pathway in surgical margins of head and neck squamous cell carcinoma (HNSCC) is a predictor of recurrence and patients with minimal residual disease may benefit from adjuvant therapy with temsirolimus, an mTOR inhibitor.

Methods:

The effects of 3 weekly doses of 25 mg of temsirolimus on Akt/mTOR pathway biomarkers were evaluated in tumor and peripheral blood mononuclear cells (PBMCs) of patients with HNSCC. Adverse events were assessed.

Results:

Temsirolimus significantly decreased pS6 and p4E‐BP1 in tumors, and pS6 and pAkt in PBMCs (p < .05). There was no significant upregulation of pAkt(Ser^473^) in tumor tissue. Side effects were minimal and reversible.

Conclusion:

Significant inhibition of the mTOR pathway was noted in both tumors and PBMCs of HNSCC with minimal side effects. The mTOR inhibitors can potentially be used as adjuvant therapy for patients with minimal residual disease and PBMCs are potential surrogate markers in this setting. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

📜 SIMILAR VOLUMES

CT of the chest and abdomen in patients

CT of the chest and abdomen in patients with newly diagnosed head and neck squamous cell carcinoma

✍ Harri T. Keski-Säntti; Antti T. O. Markkola; Antti A. Mäkitie; Leif J. J. Bäck; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

## Background: The benefits of ct scanning of the chest and abdomen as a routine screening method for patients with newly diagnosed head and neck squamous cell carcinoma (hnscc) remain unclear. ## Methods: Consecutive patients with a primary hnscc (t classification, t2-t4) and or regionally metas

Efficacy of neck treatment in patients w

Efficacy of neck treatment in patients with head and neck squamous cell carcinoma

✍ Gabriela Buck; Pia Huguenin; Sandro J. Stoeckli 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 2 views

## Abstract ## Background. Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the

Using TNM staging to predict survival in

Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck

✍ Stephen F. Hall; Patti A. Groome; Deanna Rothwell; Peter F. Dixon 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 3 views

## Background: There is a need for a classification system for prognosis based on the tnm system for patients with squamous cell carcinoma of the head and neck such that patient groupings are homogeneous within and heterogeneous between. ## Methods: Six hundred fifty-five consecutive patients wit

Treatment of the neck in patients with s

Treatment of the neck in patients with squamous cell carcinoma of the head and neck

✍ Richard H. Jesse; Gilbert H. Fletcher 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 English ⚖ 422 KB 👁 2 views

Immunoglobulin allotypes in patients wit

Immunoglobulin allotypes in patients with squamous cell carcinoma of the head and neck

✍ Theodorus Ockhuizen; Janardan P. Pandey; Robert W. Veltri; Myron Arlen; H. Hugh 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB 👁 2 views

Gm, A2m, and Km allotypic markers were examined in 40 Caucasian patients with squamous cell carcinomas of the head and neck. Serum IgA levels, the A2m(l) allotypic marker, and antibodies against IgAl, A2m(l), and A2m(2) were measured quantitatively. The frequency of Km(1) was found to be significant

Differences in history of sexual behavio

Differences in history of sexual behavior between patients with oropharyngeal squamous cell carcinoma and patients with squamous cell carcinoma at other head and neck sites

✍ Kristina R. Dahlstrom; Guojun Li; Guillermo Tortolero-Luna; Qingyi Wei; Erich M. 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 1 views

## Abstract ## Background. An emerging epidemic of human papillomavirus (HPV)‐associated oropharyngeal cancer has been proposed. The purpose of this study was for us to compare the sexual behaviors of patients with squamous cell carcinoma of the oropharynx (SCCOP) and patients with squamous cell c