## Abstract ## Background: Activation of the mammalian target of rapamycin (mTOR) pathway in surgical margins of head and neck squamous cell carcinoma (HNSCC) is a predictor of recurrence and patients with minimal residual disease may benefit from adjuvant therapy with temsirolimus, an mTOR inhibi
CT of the chest and abdomen in patients with newly diagnosed head and neck squamous cell carcinoma
✍ Scribed by Harri T. Keski-Säntti; Antti T. O. Markkola; Antti A. Mäkitie; Leif J. J. Bäck; Timo S. Atula
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 117 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1043-3074
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
The benefits of ct scanning of the chest and abdomen as a routine screening method for patients with newly diagnosed head and neck squamous cell carcinoma (hnscc) remain unclear.
Methods:
Consecutive patients with a primary hnscc (t classification, t2-t4) and or regionally metastatic disease (ie, n+) were eligible for inclusion. patients who were considered incurable and patients with recurrent disease were excluded. ct scans of the chest and abdomen were performed.
Results:
We examined 100 patients. two patients had pulmonary metastases at presentation. an occult aortic aneurysm required surgical repair before anticancer therapy in one patient. in many patients, nonspecific ct findings warranted further examinations or close follow-up. the abdominal ct was negative for metastatic hnscc in all patients.
Conclusions:
Routine ct screening of the chest and abdomen resulted in upstaging of disease in two patients (2%) and altered the treatment approach in three patients (3%). abdominal ct does not seem beneficial in patients with previously untreated hnscc. chest ct is not indicated routinely.
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