Spina bifida cystica (SB) is one of the most common and disabling of birth defects. Folic acid supplementation in mothers during the periconceptional period has been shown to prevent more than 70% of neural tube defects (NTD) including SB. However, the mechanism is unknown. We tested a series of mul
β¦ LIBER β¦
Evaluation of the MTHFR C677T allele and the MTHFR gene locus in a German spina bifida population
β Scribed by Koch, M. C.; Stegmann, K.; Ziegler, A.; Schröter, B.; Ermert, A.
- Book ID
- 113042883
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 328 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0340-6997
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## Abstract Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677Cβ>T and 1298Aβ>C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status. This study was designed to determine the rate of MTHFR 677C