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Population distribution of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C risk alleles for methotrexate toxicity in Israel

โœ Scribed by Edna Efrati, Hela Elkin, Sagi Nahum, Norberto Krivoy


Book ID
120780169
Publisher
Springer
Year
2012
Tongue
English
Weight
174 KB
Volume
33
Category
Article
ISSN
0172-8172

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Methylenetetrahydrofolate reductase (MTH
โœ Rady, Peter L.; Tyring, Stephen K.; Hudnall, S. David; Vargas, Trini; Kellner, L ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 36 KB ๐Ÿ‘ 2 views

The polymorphic mutation C677T in the gene of MTHFR is considered a risk mutation for spina bifida and vascular disease. Another common mutation on the MTHFR gene, A1298C, has also been described as another risk mutation. We studied the frequencies of these two mutations on DNA samples from healthy