Spina bifida cystica (SB) is one of the most common and disabling of birth defects. Folic acid supplementation in mothers during the periconceptional period has been shown to prevent more than 70% of neural tube defects (NTD) including SB. However, the mechanism is unknown. We tested a series of mul
Smoking behavior and the C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene
β Scribed by Johnson*, William G. ;Spychala, John R. ;Stenroos, Edward S. ;Scholl, Theresa O. ;Schroeder, Christine M.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 59 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0148-7299
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Different lines of evidence indicate that methylenetetrahydrofolate reductase (__MTHFR__) functional gene polymorphisms, causative in aberrant folateβhomocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders. Opposing views are exp
The polymorphic mutation C677T in the gene of MTHFR is considered a risk mutation for spina bifida and vascular disease. Another common mutation on the MTHFR gene, A1298C, has also been described as another risk mutation. We studied the frequencies of these two mutations on DNA samples from healthy