of sex ratios in children with different MTHFR
The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine
โ Scribed by Kowa, Hisanori ;Yasui, Kenichi ;Takeshima, Takao ;Urakami, Katsuya ;Sakai, Fumihiko ;Nakashima, Kenji
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 73 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0148-7299
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The polymorphic mutation C677T in the gene of MTHFR is considered a risk mutation for spina bifida and vascular disease. Another common mutation on the MTHFR gene, A1298C, has also been described as another risk mutation. We studied the frequencies of these two mutations on DNA samples from healthy
Methylenetetrahydrofolate reductase (MTHFR) catalyses the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for homocysteine remethylation to methionine. Severe MTHFR deficiency is associated with hyperhomocysteinemia and homocystinuria. These patients show a wi