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Evaluation of the Effects of Bitopertin (RG1678) on Cardiac Repolarization: A Thorough Corrected QT Study in Healthy Male Volunteers

✍ Scribed by Hofmann, Carsten; Banken, Ludger; Hahn, Michael; Swearingen, Dennis; Nagel, Sandra; Martin-Facklam, Meret


Book ID
119218640
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
804 KB
Volume
34
Category
Article
ISSN
0149-2918

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## Introduction Dapagliflozin is a first-in-class sodium-glucose transporter 2 (SGLT2) inhibitor under investigation for the treatment of type 2 diabetes mellitus. A thorough QTc study was conducted, according to International Conference on Harmonization E14 guidelines, to characterize the effect o