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Evaluation of the Effect of Naloxegol on Cardiac Repolarization: A Randomized, Placebo- and Positive-Controlled Crossover Thorough QT/QTc Study in Healthy Volunteers

✍ Scribed by Gottfridsson, Christer; Carlson, Glenn; Lappalainen, Jaakko; Sostek, Mark


Book ID
122119192
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
217 KB
Volume
35
Category
Article
ISSN
0149-2918

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## Introduction Dapagliflozin is a first-in-class sodium-glucose transporter 2 (SGLT2) inhibitor under investigation for the treatment of type 2 diabetes mellitus. A thorough QTc study was conducted, according to International Conference on Harmonization E14 guidelines, to characterize the effect o