Evaluation of the Dominant Lethal Potential of Alpha-Asarone in Male Mice
โ Scribed by Chamorro, G
- Book ID
- 123082844
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 100 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0378-4274
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Dominant lethal studies were conducted in male and female mice with a-asarone, the active hypolipidaemic component of Guatteria gaumeri Greenman, by per os sub-chronic treatment (10 and 20 mg/kg, 5 days/week, for 8 weeks) and subsequent mating. a-Asarone did not produce germinal mutations in either
Using the dominant lethal assay, the ability of fosfestrol, a diethylstilboestrol derivate, to induce mutations in male mice was tested and confirmed. Up to 300 mg/kg of fosfestrol the induction of mutations occurs exclusively in spermatozoa. A dose of 600 mg/kg of fosfestrol induces dominant lethal