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Sensitivity of dominant lethal assay in male mice

✍ Scribed by U.H. Ehling


Book ID
113249306
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
76 KB
Volume
53
Category
Article
ISSN
0165-1161

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Dominant lethal mutations in male mice
✍ U. H. Ehling πŸ“‚ Article πŸ“… 1977 πŸ› Springer-Verlag 🌐 English βš– 648 KB

Dominant lethal mutations are due to chromosome aberrations as demonstrated by analysis of first cleavage. With a sample size of 40-45 mice per dose the induction of dominant lethal mutations by 10 mg/kg of methyl methanesulfonat (MMS) can be detected in spermatids in the mating interval 9-12 days p