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Evaluation of isotopically labeled internal standards and methods of derivatization for quantitative determination of cocaine and related compounds

✍ Scribed by Sheng-Meng Wang; Meng-Yen Wu; Ray H. Liu; Russell J. Lewis; Dennis V. Canfield

Book ID
107343970
Publisher
Springer Japan
Year
2006
Tongue
English
Weight
554 KB
Volume
24
Category
Article
ISSN
1860-8965

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A quantitative GLC-mass spectrometric assay was developed for the determination of cocaine and its principal metabolite, benzoylecgonine, in human urine. The assay utilizes selective ion focusing to monitor in a GLC effluent the molecular ions of cocaine and benzoylecgonine generated by electron-imp