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An Isotopically Labeled Internal Standard Liquid Chromatography−Tandem Mass Spectrometry Method for Determination of Ephedrine Alkaloids and Synephrine in Dietary Supplements

✍ Scribed by Gay, Martha L.; Niemann, Richard A.; Musser, Steven M.


Book ID
123616677
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
114 KB
Volume
54
Category
Article
ISSN
0021-8561

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## Abstract A simple, reliable and sensitive liquid chromatography tandem mass spectrometry (LC‐MS/MS) protocol was developed and validated for quantification of bisoprolol in human plasma. The sample was pretreated with a simple procedure of protein precipitation and an isotope‐labeled d5‐bisoprol