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Evaluation of fluorine-18-labeled alkylating agents as potential synthons for the labeling of oligonucleotides

✍ Scribed by Erik F.J. de Vries; Joke Vroegh; Philip H. Elsinga; Willem Vaalburg

Book ID: 108482282
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 172 KB
Volume: 58
Category: Article
ISSN: 0969-8043
DOI: 10.1016/s0969-8043(03)00022-8

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## Abstract Uncharged derivatives of thioflavin‐T have known __in vitro__ and __in vivo__ affinity for amyloid β. We synthesized and evaluated two derivatives with a fluorine‐18 labelled fluoropropoxy substituent either at the 6‐position or at the 2′‐position of the 2‐(4′‐aminophenyl)‐1,3‐benzothia