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Evaluation of fast atom bombardment mass spectrometry for assessing the oxidation states of disulfide-containing peptides

✍ Scribed by B. S. Larsen; J. A. Yergey; R. J. Cotter

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
201 KB
Volume
12
Category
Article
ISSN
1076-5174

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✦ Synopsis

Positive and negative ion fast atom bombardment (FAB) mass spectra of the molecular ion region of calcitonin using several solution matrices produce an isotopic distribution which is indicative of a mixture of reduced and oxidized disulfide bonds. The insensitivity of the distribution to the choice of matrix and positivehegative ion mode suggest that the spectra reflect the natural abundance of reduced calcitonin in the sample, rather than an artifact of the fast atom bombardment technique.

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