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Evaluation of Biologically Based Dose–Response Modeling for Developmental Toxicity: A Workshop Report

✍ Scribed by Christopher Lau; Melvin E. Andersen; Douglas J. Crawford-Brown; Robert J. Kavlock; Carole A. Kimmel; Thomas B. Knudsen; Ken Muneoka; John M. Rogers; R.Woodrow Setzer; Gary Smith; Rochelle Tyl


Book ID
115646942
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
125 KB
Volume
31
Category
Article
ISSN
0273-2300

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✍ JAMES J. CHEN; DAVID W. GAYLOR; JAMES B. LABORDE 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 662 KB

A biologically-based dose-response model for predicting developmental malformation effects from exposure to a toxic substance during pregnancy is developed. The biological basis of this model arises from the expectation of exponential growth in rodents during gestation, and the exponential growth ra