Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB(1) (0, 0.01
Evaluation of aflatoxin B1 mutagenesis: Addition of glutathione and glutathione-S-transferase to the salmonella mutagenicity assay
โ Scribed by Jorgensen, Karen V. ;Clayton, J. Wesley ;Price, Ralph L.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1987
- Weight
- 488 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0192-2521
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Fisher-344 male rats were fed 1.6 ppm of aflatoxin B 1 (AFB 1 ) continuously and intermittently for several weeks. At various time periods, DNA was isolated from the testes and livers and analyzed for AFB 1 -DNA adducts. The ability of the testis to detoxify AFB 1 was also investigated by the glutat
We examined the effect of genetic polymorphisms of phase-II enzymes, glutathione S-transferase P1 (GSTP1) and N-acetyltrans-ferase2 (NAT2) on susceptibility to esophageal squamous-cell carcinoma. To determine the genotypes of the 2 polymorphisms, PCR-based analysis was performed on samples from 66 J