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Effects of intermittent exposures of aflatoxin B1 on hepatic and testicular glutathione S-transferase in rats

โœ Scribed by Saura C. Sahu; Ming W. Chou; Rene E. Sotomayor; Dennis M. Hinton; Curtis N. Barton; Michael W. O'Donnell

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
47 KB
Volume
20
Category
Article
ISSN
0260-437X

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โœฆ Synopsis

Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB(1) (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4-week intervals up to 20 weeks. The control animals were fed an AFB(1)-free NIH-31 diet. Rats consuming diets with 0.01 ppm AFB(1) did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB(1) at concentrations of 0.04-1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB(1) exposure.

๐Ÿ“œ SIMILAR VOLUMES

Temporal patterns of DNA adduct formatio
Temporal patterns of DNA adduct formation and glutathione S-transferase activity in the testes of rats fed aflatoxin B1: A comparison with patterns in the liver
โœ Rene E. Sotomayor; Saura Sahu; Melissa Washington; Dennis M. Hinton; Ming Chou ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 176 KB ๐Ÿ‘ 1 views

Fisher-344 male rats were fed 1.6 ppm of aflatoxin B 1 (AFB 1 ) continuously and intermittently for several weeks. At various time periods, DNA was isolated from the testes and livers and analyzed for AFB 1 -DNA adducts. The ability of the testis to detoxify AFB 1 was also investigated by the glutat