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Evaluation of a Maleimido Derivative of CHX-A′′ DTPA for Site-Specific Labeling of Affibody Molecules

✍ Scribed by Tolmachev, Vladimir; Xu, Heng; Wållberg, Helena; Ahlgren, Sara; Hjertman, Magnus; Sjöberg, Anna; Sandström, Mattias; Abrahmsén, Lars; Brechbiel, Martin W.; Orlova, Anna

Book ID
127299923
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
365 KB
Volume
19
Category
Article
ISSN
1043-1802

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The synthesis of the dexamethasone-21-maleimido-linked derivative 5 is described for the first time. The two principal steps of this synthesis are (1) the formation of a stable urethane 3 and (2) the introduction of a reactive maleimido group via a linker to get 5. This novel compound 5 is designed