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Synthesis of a dexamethasone-21-maleimido-linked derivative as a potential molecule for specific gene delivery

✍ Scribed by A Bernasconi; A Rebuffat; P Bigler; F.J Frey; B.M Frey

Book ID: 104231348
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 71 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01291-6

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✦ Synopsis

The synthesis of the dexamethasone-21-maleimido-linked derivative 5 is described for the first time. The two principal steps of this synthesis are (1) the formation of a stable urethane 3 and (2) the introduction of a reactive maleimido group via a linker to get 5. This novel compound 5 is designed to examine the interaction of the steroid with other relevant molecules or functional groups, via the formation of conjugates. The structure of 5 was proven by NMR, taking advantage of a newly developed method (HMSC).

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