Design and synthesis of a series of novel, cationic liposaccharide derivatives as potential penetration enhancers for oral drug delivery

In vitro and In vivo evaluation of posit

In vitro and In vivo evaluation of positively charged liposaccharide derivatives as oral absorption enhancers for the delivery of anionic drugs

✍ Julie A. Bergeon; Zyta M. Ziora; Adel S. Abdelrahim; Niklas U. Pernevi; Anne R. 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

Oral delivery of hydrophilic, ionisable drugs remains a major challenge in drug development and a number of active pharmaceuticals fail to reach the market of oral drugs because of a lack of absorption and/or stability issues. One possible approach to improving the bioavailability of such drug candi