Evaluation of [18F]SL702 as a prospective agonist PET radioligand for brain 5-HT1A receptors in mice and monkey
β Scribed by Shuiyu Lu; J.S. Liow; S.S. Zoghbi; R.L. Gladding; R.B. Innis; V.W. Pike
- Book ID
- 118491131
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 113 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1053-8119
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The purpose of this study was to develop a radiopharmaceutical that could be used to selectively image 5-HT 1A receptors with positron emission tomography (PET). No-carrier-added 4-(28-methoxyphenyl)-1-[28-(N-29-pyridinyl)-p-[ 18 F]fluorobenzamido]ethylpiperazine ( p-[ 18 F]-MPPF, 2) was synthesized
## Abstract This study evaluated the utility of __(S)βN__β[(1βethylβ2βpyrrolidinyl)methyl]β5β(3β[^18^F]fluoropropyl)β2,3βdimethoxybenzamide ([^18^F]fluoropropylepidepride), [^18^F]5βFPrEpid, as a ligar d for PET studies of cerebral dopamine D2 receptors. The in vitro affinity for the rat striatal d