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[18F]6FPWAY — a prospective 5-HT1A receptor radioligand — radiolabeling and pet examination in monkey — comparison with [11C]6FPWAY

✍ Scribed by J. Sandell; J. A. Mccarron; C. Halldin; V. W. Pike; B. Gulyas; Z. Cselenyi; J. Sovago; S. Marchais; H. V. Wikström; L. Farde

Book ID
112132866
Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
143 KB
Volume
44
Category
Article
ISSN
0022-2135

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Synthesis and preliminary in vivo evalua
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✍ M. Vandecapelle; F. Dumont; F. De Vos; K. Strijckmans; D. Leysen; K. Audenaert; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 138 KB 👁 1 views

## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)