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Evaluation of [11C]RTI-121 as a selective radioligand for PET studies of the dopamine transporter

✍ Scribed by Susan P. Hume; Sajinder K. Luthra; David J. Brown; Jolanta Opacka-Juffry; Safiye Osman; Sharon Ashworth; Ralph Myers; Frank Brady; F.Ivy Carroll; Michael J. Kuhar; David J. Brooks


Book ID
116172133
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
904 KB
Volume
23
Category
Article
ISSN
0969-8051

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The E isomer of (123)I-2beta-carbomethoxy-3beta-(4-fluorophenyl)-N-(1-iodoprop-1-en-3-yl)nortropane (Altropane(R)) shows high affinity (IC(50) = 6.62 +/- 0.78 nmol) and selectivity (DA/5-HT = 25) for DAT sites in the striatum. Recently, dynamic SPECT studies in healthy volunteers and patients with P