✦ LIBER ✦

Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse

✍ Scribed by F. Ivy Carroll; James L. Howard; Leonard L. Howell; Barbara S. Fox; Michael J. Kuhar

Book ID: 119986612
Publisher: American Association of Pharmaceutical Scientists
Year: 2006
Tongue: English
Weight: 238 KB
Volume: 8
Category: Article
ISSN: 1550-7416
DOI: 10.1208/aapsj080124

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Evaluation of [11C]RTI-121 as a selectiv

Evaluation of [11C]RTI-121 as a selective radioligand for PET studies of the dopamine transporter

✍ Susan P. Hume; Sajinder K. Luthra; David J. Brown; Jolanta Opacka-Juffry; Safiye 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 904 KB

Trishomocubane as a scaffold for the dev

Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands

✍ Samuel D. Banister; Iman A. Moussa; Corinne Beinat; Aaron J. Reynolds; Paolo Sch 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 309 KB

In our continued exploration of trishomocubane derivatives with central nervous system (CNS) activity, N-arylalkyl-8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes (10-13) displaying affinity for the sigma (σ) receptor were also found, in several cases, to interact with the dopamine transport

RTI-76, an isothiocyanate derivative of

RTI-76, an isothiocyanate derivative of a phenyltropane cocaine analog, as a tool for irreversibly inactivating dopamine transporter function in vitro

✍ Lijuan C. Wang; Janet L. Berfield; Michael J. Kuhar; F. Ivy Carroll; Maarten E.A 📂 Article 📅 2000 🏛 Springer-Verlag 🌐 English ⚖ 161 KB

Population pharmacokinetics, brain distr

Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse

✍ Shariq A. Syed; Amy H. Newman; Ahmed A. Othman; Natalie D. Eddington 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

A second generation of N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]-tropanes (GA 1-69, JHW 005 and JHW 013) binds with high affinity to the dopamine transporter (DAT) and are highly selective toward DAT compared to muscarinic receptor binding (M1). The objective of this study was to characteri

Probes for the dopamine transporter: New

Probes for the dopamine transporter: New leads toward a cocaine-abuse therapeutic—A focus on analogues of benztropine and rimcazole

✍ Amy Hauck Newman; Santosh Kulkarni 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 680 KB

In an attempt to discover a cocaine-abuse pharmacotherapeutic, extensive investigation has been directed toward elucidating the molecular mechanisms underlying the reinforcing effects of this psychostimulant drug. The results of these studies have been consistent with the inhibition of dopamine upta

Probes for the Dopamine Transporter: New

Probes for the Dopamine Transporter: New Leads Toward a Cocaine-Abuse Therapeutic — A Focus on Analogues of Benztropine and Rimcazole

✍ Amy Hauck Newman; Santosh Kulkarni 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views