Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients
β Scribed by Nan-Yan Rao; Zhen Hu; Jin-Ming Yu; Wen-Feng Li; Bin Zhang; Feng-Xi Su; Jiong Wu; Zhen-Zhou Shen; Wei Huang; Zhi-Ming Shao
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 250 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0167-6806
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## Abstract BARD1 (BRCA1βassociated RING domain) was identified by yeast twoβhybrid screening as a protein interacting with BRCA1. Somatic and germline mutations of __BARD1__ have been detected in sporadic breast, ovarian, and endometrial cancers. The present study represents the first description
To study the BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives, 41 patients' genomic DNA from peripheral mononuclear blood cells was studied by using single strand conformational polymorphism (SSCP) and DNA sequencing. The BRCA1 mutations were detected