The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo
Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan
β Scribed by Steven Shoei-Lung Li; H.-M. Tseng; Tsui-Ping Yang; Chia-Han Liu; Shiuh-Jen Teng; Hung-Wen Huang; L.-M. Chen; Hsiao-Wei Kao; Jimmy H. Chen; Jau-Neng Tseng; Angela Chen; Ming-Feng Hou; Tsung-Jen Huang; Hong-Tai Chang; King-Tong Mok; Juei-Hsiung Tsai
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 69 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Communicated by Mark H. Paalman Germline mutations in breast cancer susceptibility genes, BRCA1 and BRCA2, are responsible for a substantial proportion of high-risk breast and breast/ovarian cancer families. To characterize the spectrum of BRCA1 and BRCA2 mutations, we screened Czech families w
In this study we genotyped Turkish breast/ovarian cancer patients for BRCA1/BRCA2 mutations: protein truncation test (PTT) for exon 11 BRCA1 of and, multiplex PCR and denaturing gradient gel electrophoresis (DGGE) for BRCA2, complemented by DNA sequencing. In addition, a modified restriction assay w
Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2