Eukaryotic chromosome replication and the radial loop model
โ Scribed by Adam S. Wilkins
- Book ID
- 103258629
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 192 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0022-5193
No coin nor oath required. For personal study only.
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## The nuclear DNA of eukaryotes is organized into a series of loops each topologically anchored by elements of the nuclear matrix. Evidence is reviewed which indicates that the anchorage points of the loops are formed by transcriptionally active genes and that individual loops function as replicons
absolutely unfailing way. This problem is largely ignored in traditional studies on eukaryotic DNA replication. ## Summary A hypothesis for the control of eukaryotic DNA replication at the chromosomal level is proposed. The specific regulatory problem arises from the subdivision of the genome int