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Supercoiled loops and the organization of replication and transcription in eukaryotes

✍ Scribed by Barbara A. Zehnbauer; Bert Vogelstein

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
439 KB
Volume
2
Category
Article
ISSN
0265-9247

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✦ Synopsis

The nuclear DNA of eukaryotes is organized into a series of loops each topologically anchored by elements of the nuclear matrix. Evidence is reviewed which indicates that the anchorage points of the loops are formed by transcriptionally active genes and that individual loops function as replicons. The data suggests a specijic model for coupling of D N A replication

and transcription in eukaryotes.

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