Ethylene Glycol and Amino Acid Derivatives of 5-Aminolevulinic Acid as New Photosensitizing Precursors of Protoporphyrin IX in Cells
β Scribed by Berger, Yann; Greppi, Alain; Siri, Olivier; Neier, Reinhard; Juillerat-Jeanneret, Lucienne
- Book ID
- 117998483
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 281 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-2623
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Protoporphyrin IX (Pp IX) is the main photosensitizer in photochemotherapy with 5-aminolevulinic acid (ALA). Pp IX is photolabile and the present work shows that 70-95% of Pp IX in cells is degraded by clinically relevant light exposures (40-200 J cm 22 at 630 nm). During light exposure a small yiel
The bioconversion of 5-aminolevulinic acid (ALA) into hydrophobic protoporphyrin IX and other water-soluble porphyrins was investigated in Ehrlich ascite carcinoma (EAC) cells and in a myeloma cell line. The effects of irradiation (514 nm), temperature, incubation time and added glucose on the relat