✦ LIBER ✦

Estrogen- and androgen-responsive growth of human ovarian adenocarcinoma heterotransplanted into nude mice

✍ Scribed by Masumi Sawada; Nobuyuki Terada; Akira Wada; Yoichi Mori; Masato Yamasaki; Tsuneo Saga; Keigo Endo

Publisher: John Wiley and Sons
Year: 1990
Tongue: French
Weight: 648 KB
Volume: 45
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910450225

No coin nor oath required. For personal study only.

✦ Synopsis

A new line of human serous cystadenocarcinoma of the ovary, designated OVA-5, has been established in athymic nude mice. A strong correlation was noted between tumor volume and plasma CAI25 levels in mice bearing O V A 4 tumor. Growth of the O V A 4 tumor in castrated male nude mice was accelerated by S.C. administration of estradiol-I7p and 5a-dihydrotestosterone but not by progesterone. Estradiol-I7p and 5a-dihydrotestosterone also accelerated the growth of the O V A 4 tumor heterotransplanted into rialoadenectomized castrated male nude mice. No remarkable change was observed in the histological appearances of the tumors between control groups and hormone-treated groups. Receptor assays revealed that the O V A 4 tumor had both estrogen and androgen receptors. Growth of the O V A 4 tumor is thus responsive to estrogen and androgen.

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