𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Long-term inhibitory effects of a novel anti-estrogen on the growth of ZR-75-1 and MCF-7 human breast cancer tumors in nude mice

✍ Scribed by Shouqi Luo; Céline Martel; Sylvain Gauthier; Yves Mérand; Alain Bélanger; Claude Labrie; Fernand Labrie

Publisher
John Wiley and Sons
Year
1997
Tongue
French
Weight
83 KB
Volume
73
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of the novel anti-estrogen EM-343 on the growth of 2 hormone-responsive human breast cancer tumors have been examined in athymic nude mice. At the low daily dose of 5 g, EM-343 administered subcutaneously for 6 months completely blocked the stimulatory effect of endogenous estrogens on the growth of ZR-75-1 and MCF-7 tumors implanted in nude mice. In addition, uterine weight decreased by 60% while ovarian weight increased by 37%. Estrogen receptor (ER) levels measured by [ 3 H]-labeled estrogen binding were markedly reduced (by 96%, 96% and 92%) in ZR-75-1 and MCF-7 tumors, and in the mouse uterus, respectively. Accompanying the decrease in ER, progesterone receptor levels were reduced by 79%, 87% and 76%, respectively, in the above-mentioned tissues following EM-343 treatment. Our data show the pure anti-estrogenic properties of EM-343 and its high potency as an inhibitor of growth of human ZR-75-1 and MCF-7 breast tumors in nude mice.

📜 SIMILAR VOLUMES

Long-term inhibitory effect of the orall
Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice
✍ Steeve Couillard; Claude Labrie; Sylvain Gauthier; Yves Merand; Shankar Mohan Si 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 174 KB 👁 1 views

The antiproliferative effect of the new antiestrogen EM-800 has been studied during 40 weeks of treatment on human breast carcinoma ZR-75-1 xenografts in ovariectomized nude mice supplemented with estrone (0.5 g, s.c. daily). At the daily 50 g (approximately 2.5 mg/kg) oral dose, EM-800 caused a com

Characterization of the effects of the n
Characterization of the effects of the novel non-steroidal antiestrogen EM-800 on basal and estrogen-induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cells in vitro
✍ Jacques Simard; Claude Labrie; Alain Bélanger; Sylvain Gauthier; Shankar M. Sing 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 256 KB 👁 2 views

Since estrogens play a predominant role in the development and growth of human breast cancer, antiestrogens represent a logical approach to the treatment of this disease. The present study compares the effects of the novel nonsteroidal anti-estrogen EM-800 and related compounds with those of a serie