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Estimation of the human intestinal permeability of butyltin species using the Caco-2 cell line model

✍ Scribed by M.A. Azenha; R. Evangelista; F. Martel; M.T. Vasconcelos

Book ID
116461248
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
363 KB
Volume
42
Category
Article
ISSN
0278-6915

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi