𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Estimation of steady state antibiotic concentration in cerebrospinal fluid from single-dose kinetics

✍ Scribed by R. Nau; H. W. Prange

Book ID
104662420
Publisher
Springer
Year
1996
Tongue
English
Weight
247 KB
Volume
49
Category
Article
ISSN
0031-6970

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✦ Synopsis

Objective:

Assuming linear kinetics, the mean csf concentrations of an antibacterial in steady state (csscsf) can be estimated, when the area under the concentration-time curve in csf after the first dose is known. for this purpose we propose the function csscsf = auccsf.anticipated dose/dosing interval. applied dose.

Results:

Together with the mic and mbc of the causative pathogen, the estimate is of value in the choice of antibacterial drug and the dosing regimen in central nervous system infections.

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