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Kinetics of Quinolone Antibiotics in Rats: Efflux from Cerebrospinal Fluid to the Circulation

✍ Scribed by Tsuyoshi Ooie; Hiroshi Suzuki; Tetsuya Terasaki; Yuichi Sugiyama

Book ID
110344018
Publisher
Springer US
Year
1996
Tongue
English
Weight
831 KB
Volume
13
Category
Article
ISSN
0724-8741

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Estimation of steady state antibiotic co
Estimation of steady state antibiotic concentration in cerebrospinal fluid from single-dose kinetics
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## Objective: Assuming linear kinetics, the mean csf concentrations of an antibacterial in steady state (csscsf) can be estimated, when the area under the concentration-time curve in csf after the first dose is known. for this purpose we propose the function csscsf = auccsf.anticipated dose/dosing

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Brain injury has been prevented recently by systemic administration of human insulin-like growth factor-I (hIGF-I). It is widely believed that protein neurotrophic factors do not enter the brain from blood, and the mechanism by which circulating hIGF-I may be neuroprotective is uncertain. This inves