ESTIMATION OF p-AMINOSALICYLIC ACID IN BLOOD AND URINE
โ Scribed by DICKENSON, H
- Book ID
- 123322010
- Publisher
- The Lancet
- Year
- 1949
- Tongue
- English
- Weight
- 195 KB
- Volume
- 253
- Category
- Article
- ISSN
- 0140-6736
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๐ SIMILAR VOLUMES
A major chromogen found in p-aminosalicylic acid and sodium p-aminosalicylate dosage forms was identified to be 3,3'-dihydroxyazoxybenzene. This compound could he produced by oxidation or sunlight irradiation of m-aminophenol, a common impurity of paminosalicylic acid and sodium p-aminosalicylate. M
These data indicated that quantitative conversion of procarbazine hydrochloride to the azo compound occurred during the titration. No evident substitution of iodine into the phenyl ring resulted, therefore eliminating aromatic substitution as a source of interference.