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Estimation of human blood plasma 5-hydroxyindoleacetic acid and homovanillic acid

✍ Scribed by S. Wright-Honari; E. F. Marshall; C. H. Ashton; F. Hassanyeh

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 315 KB
Volume: 4
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.1130040506

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✦ Synopsis

A method for simultaneous quantification of plasma homovanillic acid and 5-hydroxyindoleacetic acid has been developed, permitting more efficient neurochemical examinations of these often interrelated biogenic amine systems. Zinc sulphate and sodium hydroxide solutions were used for precipitating the protein in plasma prior to injection on the column. This technique allows for cleaner chromatography, greater sensitivity and high precision. The method uses high performance liquid chromatographic separations of these compounds on C,* reversed phase columns with electrochemical detection. The detailed results from controls and untreated parasuicide patients are given.

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