Estimate haplotype frequencies in pedigrees
β Scribed by Qiangfeng Zhang; Yuzhong Zhao; Guoliang Chen; Yun Xu
- Book ID
- 115000690
- Publisher
- BioMed Central
- Year
- 2006
- Tongue
- English
- Weight
- 316 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2105
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## Abstract Haplotype inference for tightly linked markers from general pedigrees remains a challenging problem. Only a few methods are available to efficiently and accurately estimate haplotype frequencies and reconstruct haplotypes for a large number of tightly linked markers from general pedigre
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The present paper demonstrates algorithms for applying gene counting estimation of haplotype frequencies in very large genetic systems. A factor union representation of phenotypes is used which conveniently yields the sets of potential haplotypes and diplotypes for each phenotype. Methods for storin