Synthesis of a hybrid analog of the espe
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Harold Mastalerz; Terrence W Doyle; John F Kadow; Dolatrai M Vyas
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Article
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1996
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Elsevier Science
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French
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An enediyne analog (2, R=H) that is a hybrid of the core structures of esperamicin and dynemicin was prepared. The key step in its synthesis was a Reissert-type reaction that involved intramolecular addition of the anion of a Z-1,3-diyn-2-ene to an N-acyl tetrahydrophenathridinium intermediate. It w