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Esperamicin P, the Tetrasulfide Analog of Esperamicin A 1

โœ Scribed by Beutler, John A.; Clark, Patrick; Alvarado, A. Belinda; Golik, Jerzy


Book ID
121500122
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
343 KB
Volume
57
Category
Article
ISSN
0163-3864

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Synthesis of a hybrid analog of the espe
โœ Harold Mastalerz; Terrence W Doyle; John F Kadow; Dolatrai M Vyas ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 223 KB

An enediyne analog (2, R=H) that is a hybrid of the core structures of esperamicin and dynemicin was prepared. The key step in its synthesis was a Reissert-type reaction that involved intramolecular addition of the anion of a Z-1,3-diyn-2-ene to an N-acyl tetrahydrophenathridinium intermediate. It w