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Synthesis of intermediates for the preparation of core analogs of esperamicin

โœ Scribed by Harold Mastalerz; Terrence Doyle; John Kadow; Kinwa Leung; Dolatrai Vyas

Book ID
103400256
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
211 KB
Volume
36
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES

Synthesis of a hybrid analog of the espe
Synthesis of a hybrid analog of the esperamicin and dynemicin cores
โœ Harold Mastalerz; Terrence W Doyle; John F Kadow; Dolatrai M Vyas ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 223 KB

An enediyne analog (2, R=H) that is a hybrid of the core structures of esperamicin and dynemicin was prepared. The key step in its synthesis was a Reissert-type reaction that involved intramolecular addition of the anion of a Z-1,3-diyn-2-ene to an N-acyl tetrahydrophenathridinium intermediate. It w

Synthesis of an esperamicin core analog
Synthesis of an esperamicin core analog with an epoxide trigger
โœ Harold Mastalerz; Terrence W Doyle; John F Kadow; Dolatrai M Vyas ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 198 KB

An esperamicin core analog 4 with an epoxide trigger like that found in the related enediyne, dynemicin, was prepared. Surprisingly, it was found to be relatively stable; the p-aminophenyl substituent did not facilitate epoxide solvolysis to the extent that had been anticipated. A mild acid, pyridin