Erratum to: Interleukin-15 plays an essential role in the pathogenesis of autoimmune diabetes in the NOD mouse
✍ Scribed by D. Bobbala, X.-L. Chen, C. Leblanc, M. Mayhue, J. Stankova, T. Tanaka…
- Book ID
- 120906365
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 71 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0012-186X
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Interleukin-1 (IL-1) costimulation is required for efficient IL-2 synthesis and IL-2 receptor (IG2R) expression of T cells. The molecular events leading to these effects are largely unknown. We utilized an IL-1-responsive and an IL-1non-responsive subclone of the mouse thymoma cell line EL4 to inves
The nonobese diabetic (NOD) mouse spontaneously develops an autoimmune diabetes that shares many immunogenetic features with human insulin-dependent diabetes mellitus (IDDM), type 1 diabetes. The mononuclear cell infiltrates in the islet, which results in the development of insulitis (a prerequisite