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Fas/Fas Ligand Interactions Play an Essential Role in the Initiation of Murine Autoimmune Diabetes

✍ Scribed by Nakayama, M.; Nagata, M.; Yasuda, H.; Arisawa, K.; Kotani, R.; Yamada, K.; Chowdhury, S. A.; Chakrabarty, S.; Jin, Z. Z.; Yagita, H.; Yokono, K.; Kasuga, M.


Book ID
126607609
Publisher
American Diabetes Association
Year
2002
Tongue
English
Weight
185 KB
Volume
51
Category
Article
ISSN
0012-1797

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The exact process that leads to the eruption of autoimmune reactions against beta cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis.